A few weeks ago I ordered a test from ConnectMyDNA via a LivingSocial special. I received my results back recently and they were... interesting. I knew that this was not an ancestry / genealogy DNA test, but rather it compares your DNA to current populations. I was curious: was my DNA more similar to the English, German or some other European?
Well, according to ConnectMyDNA, my DNA is more Malaysian. Um, what? Here's the breakdown:
I was more than a bit confused by the results. There are only three European countries on the list, Sweden, Ireland and Slovenia. The rest are asian or hispanic countries. I don't know how my results could possibly be correct, even understanding that colonization mixed European DNA into populations throughout the world.
I emailed ConnectMyDNA to find out more about why my results came out the way they did. I got a response that seems pretty copy and paste:
"Thank you for your inquiry. ConnectMyDNA™ is not an ancestry test. ConnectMyDNA™ utilizes current databases that represent the modern world population structure. ConnectMyDNA™ provides you with a Gene Ring™ and the populations with which you share the most similarity. Your unique DNA signature is used to calculate the frequency of occurrence of your DNA profile with different population databases from around the world using a standard population genetics formula known as the Hardy-Weinberg equation. The numerical value of the different calculations identifies your top country connection. Your top country connection represents the population that you most closely resemble based on today’s demographics."Ok, I tried to do some research on this, but science is not my thing. It appears that Hardy and Weinberg came up an equation that explains how the frequency of genotypes and alleles stay the same generation by generation and will not change under certain conditions. Pretty much ConnectMyDNA plugged my DNA into an equation and came up with these results. Their response to my email was not specific to my question or my DNA, and was not a very helpful.
There may be a reason that my results came back the way they did, but I can't understand how they could be correct. How can I have mostly pure European DNA and be more closely related to an Asian population?
Simply put, I don't trust the results and would not recommend that anyone purchase a ConnectMyDNA test.
UPDATE: This message was posted on the ConnectMyDNA Facebook page in response to customer concerns:
"Here is some additional information on ConnectMyDNA that may shed some additional light to the results.
Although there is no real simple way to explain some of the science involved, one way to express or explain your results is through Population Genetics. Population Genetics is a branch of genetics that focuses on how frequently genes occur in a population and once determined, how frequently combinations of genes (genotypes) should occur. For example, if a gene has two forms (alleles) in a population, they can be referred to as x and y. Allele x is found at a frequency of 10% in the population while allele y is found at a frequency of 90% (total adds up to 100%). A different population may have the same two alleles, but their frequencies may be different. Since each person contains two copies of a gene, one from each biological parent, there are three possible genotypes; x/x, x/y, and y/y. These three genotypes will occur in a frequency proportional to the individual allele frequencies and can be calculated using a standard Population Genetics equation known as the Hardy-Weinberg Equation. In this case the three genotypes are expected to occur at a frequency of: x/x is (0.1 x 0.1) = 1%; x/y is (2 x 0.1 x 0.9) = 18%; y/y = (0.9 x 0.9) = 81%.
ConnectMyDNA uses these principles in providing information about the population groups you share the most statistical similarity. Since the markers used to generate your unique DNA profile are weakly affiliated with ancestry, your connection will likely not match your expectations in terms of ancestry.
ConnectMyDNA is a fun and unique way to take 13 markers, a very small fragment of your own personal fingerprint and compare these to the same 13 markers of others around the world. It just so happens that those same markers are more prominent in your #1 country match.
If we were to expand and include other markers in this comparison, the results could change and become more refined and would perhaps show more of your ancestry if we also included markers used in ancestry testing. This also holds true if we were to add additional population databases as these could change the population order. ConnectMyDNA will always pick the top 5-10 matches, even if the most appropriate database is not included in the mix.
In a world that thrives on social connections CMD is a easy way to get people interested in learning more about themselves and create ways to connect with others with new commonality.
ConnectMyDNA uses these principles in providing information about the population groups you share the most statistical similarity. Since the markers used to generate your unique DNA profile are weakly affiliated with ancestry, your connection will likely not match your expectations in terms of ancestry.
ConnectMyDNA is a fun and unique way to take 13 markers, a very small fragment of your own personal fingerprint and compare these to the same 13 markers of others around the world. It just so happens that those same markers are more prominent in your #1 country match.
If we were to expand and include other markers in this comparison, the results could change and become more refined and would perhaps show more of your ancestry if we also included markers used in ancestry testing. This also holds true if we were to add additional population databases as these could change the population order. ConnectMyDNA will always pick the top 5-10 matches, even if the most appropriate database is not included in the mix.
In a world that thrives on social connections CMD is a easy way to get people interested in learning more about themselves and create ways to connect with others with new commonality."